Freeze Drying Systems
From hightech pilot plants up to high efficiency production plants
Optima Pharma’s modern manufacturing site is state of the art. All the required media for the different processes are available: Clean steam, CIP water and liquid nitrogen. The construction, commissioning and FAT of the freeze drying unit takes place in our split level facility. Freeze drying units can be installed, tested and operated under real conditions, saving time and money for qualification (IQ/OQ) and the final site installation (SAT).
Freeze drying systems from OPTIMA pharma
Innovative forward-looking technologies to meet your unique requirements
Your needs are in focusThe design of new plants and the refurbishment or upgrading of existing plants is dependent on many factors. Process requirements,
product characteristics and your spatial limitations are all being considered during design. The desired level of automation (manual, semi-automatic or fully automatic) is a key factor in the selection of the loading system. Optima pharma offers exactly the right solution for your requirements. Manufacture, test, installation and commissioning of loading and unloading systems and freeze drying
units can be performed at the facility in Mornshausen.
Modern building infrastructureFor the installation and operation of the units under real conditions. Single floor as well as dual floor units can be built and installed to mimic the architecture of the final site, thereby allowing simulation of potential conflicts prior to site installation. The installation / de-installation as well as the transport is fully prepared in the factory. The units are shipped in sealed trucks. This ensures optimal delivery at the installation site and speeds the installation on-site, saving valuable time to commissioning and production.
Further InformationGet more information on freeze drying systems, solutions and services from OPTIMA pharma.
Lyophilization Process Technology
Focus on process safety and efficiency. Interview partner: Stephan Reuter, CEO Optima Pharma
What is lyophilization?
Information about lyophilization technology
Freeze-drying, also known as lyophilization or sublimation drying is a method for the careful drying of high quality products. In freeze-drying the ice crystals sublimate directly without passing into liquid state. The end product of freeze-drying is known as lyophilization. Lyophilization in the pharmaceuticals industry is undertaken as a batch process.
As a rule the freeze-drying system is comprised of two containers. Chamber and condenser vessel are connected to each other via a valve (intermediate valve). The product to be dried stands on heatable and coolable surfaces and is frozen under atmospheric pressure. Coiled pipes are built into the condenser with a flow-through directly via injection of refrigeration agent or through a freezing solution.
In the primary drying phase the water contained in the material is sublimated. This is based on the principle that also when frozen, water has sufficiently high vapor pressure to pass from frozen directly to gaseous state. For this a vacuum is created.
Energy is taken up in sublimation. This energy is drawn from the surrounding temperature and so in the course of the process the temperature of the set-up surface would drop. In order to keep the temperature constant the set-up surfaces are subjected to the same amount of heat as is taken up by the water as sublimation energy. In the course of the drying process the atmosphere in the chambers consists almost exclusively of water vapor that precipitates as ice on the cold coiled pipes of the condenser.