Smart solutions for pharma experts – lyophilization expertise
Expertise in freeze-drying
Modular freeze-drying systems with individual customization – these are the freeze-drying systems available from OPTIMA pharma
Optima provides freeze-drying solutions for all production sizes, from small batches for clinical trials to large production batches. Their modular design means that your processes are scalable and the systems can be optimally adapted to suit your production infrastructure.
Our expertise comes from a combination of our in-depth knowledge of the latest lyophilization solutions and cutting edge engineering technology. Comprehensive turnkey project management massively reduces the complexity of project control, from interdisciplinary consulting to uniform interfaces and documentation to the centralized SCADA system for the entire plant.
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Skills and expertise
Our skills throughout the entire process chain
Fields of application
Optima Pharma's freeze-drying systems are being used in the biotech industry, among others. Our deep understanding of the processes required here means that we can offer you specific solutions for diverse, highly complex end products. This is the best way to ensure the effectiveness of your biotech products.
Highly potent active ingredients
Highly potent active ingredients make very particular demands on Fill & Finish technology and on freeze-drying. Our recipe for success is our comprehensive consulting, design, and implementation process.
Since the Covid-19 pandemic began, mRNA vaccines have found themselves increasingly in the spotlight of the pharmaceutical and biotech industries. One option for stabilizing active ingredients is freeze-drying. This allows them to be stored and transported in a solid form at room temperature.
Peptides & oligonucleotides
Pharmaceutical companies are increasingly using peptides and oligonucleotides as active ingredients in biopharmaceuticals. Worldwide demand is increasing. With freeze-drying processes, peptides are turned into a solid form and are stored and transported optimally.
Viral vectors are often used for gene transfer, e.g. in cell and gene therapy. These biologicals are structurally highly complex. Optimized formulations and pilot freeze dryers are utilized to develop customized freeze drying cycles that are both robust and efficient. This means that in the future, you will no longer have to rely on frozen storage and will successfully be able to make virus activity secure during transport and storage at room temperature.
55 percent of the companies that process blood plasma are Optima Pharma customers. Our four principles also apply to freeze-drying: Minimization of product loss, process stability, productivity, and flexibility as well as a safe, aseptic process.
In diagnostics fewer and fewer instruments, specific skills and training are required. This opens up great opportunities for freeze drying. Freeze-dried beads can be configured so that one bead contains everything needed for an assay or POC test.
The diagnostics focus on highly sensitive solutions and suspensions. Here, we concentrate on the specific requirements of manufacturers in two areas: firstly, applications in human and veterinary diagnostics, and secondly, life science research.
The ideal freeze-drying system for every production infrastructure
Compact and flexible
Are you on the lookout for multitalent? You will find what you are looking for with Freeze Dryer C, as it combines a space-saving footprint with maximum flexibility. This compact freeze dryer is ideally suited for use in multi-system concepts and is optimized to be integrated into your existing machinery.
Small batches freeze-dried
The CS freeze dryer gives you maximum flexibility. It is designed for products that are new to the market and are initially being produced in small and medium quantities. The CS freeze dryer is designed to be optimally installed in existing structures.
Do you need a high-performance freeze dryer for blockbusters? Optima Pharma can also provide the right solution for this requirement under the name LYO / S. The freeze dryer S allows you to freeze-dry large quantities safely.
Suitable for functional floor
Its special two-story construction means that the D freeze dryer can be easily integrated into existing plant designs. Its slender footprint allows it to be integrated into even the tightest of spaces.
Loading and unloading Systems
Innovative, future-oriented solutions - tailor-made for your customized application
Loading and unloading is done row-by-row. Feeding objects and assembling rows is performed with a certain number of objects (depending on the plate width and the diameter of the objects). These are then fully slid into the freeze dryer. In the unloading process, each row is again separated and transferred to the downstream machines.
The objects are packed into individual batches and placed into frames. The vial packages in the frames can then be loaded and unloaded. After the unloading process, the frames are removed, the vial packages are unloaded and the objects are fed into the downstream machines.
SCADA systems, visualization
Future-proofing thanks to virtualization
Our SCADA solutions enable you to network your production with different IT architectures. As your partner in automation, we know your processes in detail, all the way from formulation development to the needs of the plant operators and service experts. That is why Optima's high-tech production plants are equipped with SCADA and HMI solutions that are perfectly adapted to suit your production processes and are easy to operate.
We develop solutions in close cooperation with you, whether they are for freeze dryers or as a fully integrated automation or process solution for turnkey plants that are installed worldwide. Our SCADA systems can be extended and upgraded at any time by virtualization at the outset, avoiding technology disruptions and the need for completely new project planning.
Modular freeze-drying systems combined with individual customization
Processing highly potent active substances requires special measures. Optima Pharma has created a comprehensive, end-to-end process for this.
Quality assurance is part of the process of continuous improvement. Our PAT tools, including mass spectrometers, provide continuous real-time quality assurance.
We use our extensive process knowledge to make freeze drying faster, safer, more efficient, and compatible with every requirement. This knowledge is also necessary for defining the suitable design space and the cycle to achieve optimal productivity in the laboratory as well as in the production facility.
Optima Pharma uses modern, environmentally friendly refrigerants, as well as natural substances such as liquid nitrogen (LN2), air, and combustible gases. After carrying out a financial analysis, the best choice can always be defined.
OPTIMA Total Care
A strong life cycle management program for successful production
The packaging processes of the future will become more efficient, digitally networked, and more complex. We can help you in these areas. At Optima, personal and individual customer care is a top priority. Choose the best support from our comprehensive OPTIMA Total Care portfolio to achieve your objectives quickly and efficiently.
Our consultants and experts will be on hand to support you – at any time, throughout your plant's entire life cycle. We always keep an eye on your needs, aims and success. You can rely on us.
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Things worth knowing about freeze-drying
Information on the lyophilization process
Discover the fascinating technology of our LYO-CS freeze dryer, which allows small batches to be freeze-dried cost-effectively. In the video animation, you can see what makes the system so flexible. What characterizes the LYO-CS is its minimal footprint, fast commissioning, and high levels of flexibility.