Smart solutions for pharma experts – lyophilization expertise

Expertise in freeze-drying

Modular freeze-drying systems with individual customization – these are the freeze-drying systems available from OPTIMA pharma

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Skills and expertise

Our skills throughout the entire process chain

Machine types 
System Types

Optima Pharma develops freeze-drying solutions for the mass production of pharmaceutical products, as well as for the diagnostics and laboratory sectors.


Loading and unloading systems
Loading and Unloading Systems

There are loading and unloading systems to complement your freeze dryer. Manually supported as well as semi-automated and fully automated solutions are available.


SCADA systems, visualization
SCADA Systems, Visualization

Highly individual software modules based on the Siemens PCS7 and Rockwell FactoryTalk will put your plant at the cutting edge of technology.


Green Technology

Our many years' experience ensures that you get the most suitable, reliable, and trouble-free process technology for your specific needs.


Fields of application



Optima Pharma's freeze-drying systems are being used in the biotech industry, among others. Our deep understanding of the processes required here means that we can offer you specific solutions for diverse, highly complex end products. This is the best way to ensure the effectiveness of your biotech products.

High Potent

Highly potent active ingredients

Highly potent active ingredients make very particular demands on Fill & Finish technology and on freeze-drying. Our recipe for success is our comprehensive consulting, design, and implementation process. 


mRNA vaccines

Since the Covid-19 pandemic began, mRNA vaccines have found themselves increasingly in the spotlight of the pharmaceutical and biotech industries. One option for stabilizing active ingredients is freeze-drying. This allows them to be stored and transported in a solid form at room temperature.


Peptides & oligonucleotides

Pharmaceutical companies are increasingly using peptides and oligonucleotides as active ingredients in biopharmaceuticals. Worldwide demand is increasing. With freeze-drying processes, peptides are turned into a solid form and are stored and transported optimally.

Cell and gene therapies

Viral vectors

Viral vectors are often used for gene transfer, e.g. in cell and gene therapy. These biologicals are structurally highly complex. Optimized formulations and pilot freeze dryers are utilized to develop customized freeze drying cycles that are both robust and efficient. This means that in the future, you will no longer have to rely on frozen storage and will successfully be able to make virus activity secure during transport and storage at room temperature.

Blood Plasma

Blood plasma

55 percent of the companies that process blood plasma are Optima Pharma customers. Our four principles also apply to freeze-drying: Minimization of product loss, process stability, productivity, and flexibility as well as a safe, aseptic process.

Freeze-dried beads

Freeze-dried beads

In diagnostics fewer and fewer instruments, specific skills and training are required. This opens up great opportunities for freeze drying. Freeze-dried beads can be configured so that one bead contains everything needed for an assay or POC test.



The diagnostics focus on highly sensitive solutions and suspensions. Here, we concentrate on the specific requirements of manufacturers in two areas: firstly, applications in human and veterinary diagnostics, and secondly, life science research. 

Machine types

The ideal freeze-drying system for every production infrastructure

Compact and flexible
Freeze Drying Solution Machine LYO C
Small batches freeze-dried
Freeze Drying Solution Machine LYO CS
Freeze-drying large
quantities safely
Freeze Drying Solution Machine LYO S
Suitable for functional floor
Freeze Drying Solution Machine LYO D
Comparison of system types
Download product data sheet 
System Types
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Loading and unloading Systems

Innovative, future-oriented solutions - tailor-made for your customized application

Our loading and unloading systems are tailor-made to meet your needs and requirements, and they are designed to take into account the capacity and number of freeze dryers and production conditions. Our portfolio ranges from manual solutions to robot-controlled systems. Automatic loading and unloading systems improve your process reliability, save time, and boost productivity.
Row-by-row system
Loading and Unloading Systems

Loading and unloading is done row-by-row. Feeding objects and assembling rows is performed with a certain number of objects (depending on the plate width and the diameter of the objects). These are then fully slid into the freeze dryer. In the unloading process, each row is again separated and transferred to the downstream machines.

Frame loading
Frame Loading

The objects are packed into individual batches and placed into frames. The vial packages in the frames can then be loaded and unloaded. After the unloading process, the frames are removed, the vial packages are unloaded and the objects are fed into the downstream machines.


SCADA systems, visualization

Future-proofing thanks to virtualization

Our SCADA solutions enable you to network your production with different IT architectures. As your partner in automation, we know your processes in detail, all the way from formulation development to the needs of the plant operators and service experts. That is why Optima's high-tech production plants are equipped with SCADA and HMI solutions that are perfectly adapted to suit your production processes and are easy to operate.
We develop solutions in close cooperation with you, whether they are for freeze dryers or as a fully integrated automation or process solution for turnkey plants that are installed worldwide. Our SCADA systems can be extended and upgraded at any time by virtualization at the outset, avoiding technology disruptions and the need for completely new project planning.


Modular freeze-drying systems combined with individual customization 

High Potent

High potent

Processing highly potent active substances requires special measures. Optima Pharma has created a comprehensive, end-to-end process for this.


Process Analytical Technology (PAT)
Process Analytical
Technology (PAT)

Quality assurance is part of the process of continuous improvement. Our PAT tools, including mass spectrometers, provide continuous real-time quality assurance.


Process Optimization

Process optimization

We use our extensive process knowledge to make freeze drying faster, safer, more efficient, and compatible with every requirement. This knowledge is also necessary for defining the suitable design space and the cycle to achieve optimal productivity in the laboratory as well as in the production facility.

Green Technology

Green technology

Optima Pharma uses modern, environmentally friendly refrigerants, as well as natural substances such as liquid nitrogen (LN2), air, and combustible gases. After carrying out a financial analysis, the best choice can always be defined.

OPTIMA Total Care

A strong life cycle management program for successful production

OPTIMA Total Care

The packaging processes of the future will become more efficient, digitally networked, and more complex. We can help you in these areas. At Optima, personal and individual customer care is a top priority. Choose the best support from our comprehensive OPTIMA Total Care portfolio to achieve your objectives quickly and efficiently.

Our consultants and experts will be on hand to support you – at any time, throughout your plant's entire life cycle. We always keep an eye on your needs, aims and success. You can rely on us.

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Things worth knowing about freeze-drying

Information on the lyophilization process

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Freeze-drying is a process where the product is first deep-frozen and then dried at a low temperature by removing the water contained in it in the form of ice, using a special vacuum process. At low temperatures, the ice crystals within the product change from a solid state directly into a gaseous state, without first becoming liquid. It has the advantage that when drying at low temperatures, ice has sufficiently high vapor pressure to pass directly from the frozen to a gaseous state. This means that high-quality and sensitive products can be dried in a particularly gentle way, allowing their structure and texture to remain intact.

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Discover the fascinating technology of our LYO-CS freeze dryer, which allows small batches to be freeze-dried cost-effectively. In the video animation, you can see what makes the system so flexible. What characterizes the LYO-CS is its minimal footprint, fast commissioning, and high levels of flexibility.