In the pharmaceutical world, these are playing an increasing role: transdermal therapeutic systems (TTS) are applied to the skin, where they release active ingredients in a controlled manner.
The advantage is that the drugs directly enter the bloodstream so they do not affect the gastrointestinal tract or liver.As a manufacturer, you face a number of challenges in TTS development and production: the highly viscous and pressure-sensitive adhesives require both cohesive and adhesive properties. They must reliably release the active ingredient without irritating the skin or triggering allergies.
In this case, you will benefit from our core competence: handling materials with diverse physical properties. Systems with constant web tension, precision cutting quality, and in-line inspection ensure safe and highly efficient processes. When are you going to opt for the end-to-end, cost-effective solution for converting, and the primary and secondary packaging we offer?
We work with you to configure your system technology on a platform basis. You can count on the winning triple formula for success: excellent plant efficiency, output, and utilization of your raw materials.
Cutting stations, laminating and delaminating units, or printing systems: with Optima, all processes seamlessly intertwine. The result is the careful and economical use of your valuable active ingredients. Right from the configuration stage, we ensure your system meets all the requirements of the regulatory authorities. We also offer machine qualification and validation in compliance with the FDA and EMA.
If needed, our technical center can let you use a testing machine for the new and further development of transdermal patches and oral film strips. Afterward, we will transfer the processes or machine modules developed there into a production machine tailored to your needs.
Is everything as it should be? This is checked by sensors and camera systems during the one hundred percent in-process monitoring. Depending on the application, matrix or line scan cameras are used for this purpose. Thanks to transmitted or reflected light illumination, they accurately identify even the smallest defects. This means that only acceptable items make it through the process.
By the way, the camera systems also perform complex web control tasks – making your system even more effective.
Your freshly made transdermal patches and oral film strips are sealed in pouches by a plate sealing module. The sealing unit is supplied with one or multiple lanes. Good to know: sealing pressure, sealing temperature, and sealing time are continuously monitored and logged by your system. In addition, the packaging film can be printed in a variety of ways and the print checked afterward.
From a compact converting machine for development and clinical trials to a super-fast manufacturing line that includes primary and secondary packaging: together, we will configure your ideal system.
Oral film strips and transdermal patches are a well-tolerated form of administering medication. The OPTIMA TDC 125 offers you an ideal entry into producing small to medium quantities. It is also ideal for product development and clinical testing in the lab. The system can produce up to 200 products per minute.